Questions: 6630 week 2 knolwedge check

6630 week 2 knolwedge check.Which natural agonists have similar effects to morphine by activating the opioid receptors?

Norepinephrine
Fentanyl
Endorphins
Epinephrine

Question 2 (1 pt)

Which term describes the ability of a drug to cause a biological effect?

Potency
Agonism
Affinity
Efficacy
Incidence

Question 3 (1 pt)

What is the first-pass effect?

Release of a drug’s active ingredient from its formulation
Drug metabolism in the liver before reaching systemic circulation
Immediate drug effect upon first administration
Initial drug distribution and plasma protein binding
Complete drug elimination after first use

Question 4 (1 pt)

Which statement most accurately describes a drug with high efficacy and high potency?

It requires a large dose to exert a significant effect.
It requires only a small dose to exert a significant effect.
The maximum dose does not cause a significant effect.
Even a large dose will not cause a significant effect.
No dose change will lead to a change in the clinical effect.

Question 5 (1 pt) 6630 week 2 knolwedge check

Nortriptyline is metabolized by cytochrome P450 2D6. Which statement regarding homozygotes for inactive alleles of cytochrome P450 2D6 is most accurate?

Homozygotes for inactive alleles of cytochrome P450 2D6 are not possible.
They require a higher dose of nortriptyline to achieve the same concentration seen in heterozygotes.
They have lower nortriptyline levels in the blood than patients with 2 active genes.
They have higher nortriptyline levels in the blood than heterozygotes.
They require a higher dose of nortriptyline to achieve the same concentration seen in patients with 2 active genes.

Question 6 (1 pt) 6630 week 2 knolwedge check

To cross the blood-brain barrier, a drug molecule should possess which of the following characteristics?

Highly lipophilic with small molecular mass
Highly lipophilic with high molecular mass
Neutral with high molecular mass
Highly hydrophilic with high molecular mass
Highly hydrophilic with small molecular mass

Question 7 (1 pt)

What non-pharmacological method of pain relief is hydrotherapy considered?

Divergent
Cutaneous
Sensory
Cognitive

Question 8 (1 pt)

A patient is being treated for depression with a specific medication. The pharmacokinetic profile of this medication reveals a dissociation constant (Kd) of 344 pg/ml and an effective dose for 50% of the population (ED50) of 200 pg/ml. What can be inferred from these pharmacokinetic parameters?

An ED50 lower than Kd suggests the drug is ineffective.
The presence of spare receptors can be inferred from these values.
The medication is likely to cause severe side effects due to high potency.
The drug requires full receptor saturation to be effective, as indicated by the Kd and ED50 values.
The drug’s high Kd value indicates it has a very high binding affinity.

Question 9 (1 pt)

What effect does an antagonist drug have over the receptors?

Causes the associated cellular process to be blocked
Stimulates bronchodilation in the lungs
Causes the associated cellular process to be activated
Increases the heart rate

Question 10 (1 pt)

A parent drug is primarily polarized during which phase(s) of drug metabolism?

Phase 2
Phase 1
All phases
Phases 2 and 3

More quizzes

Answer Guide:6630 week 2 knolwedge check

Question 1 (1 pt)

Which natural agonists have similar effects to morphine by activating the opioid receptors?

Norepinephrine
Fentanyl
Endorphins (Correct Answer)
Epinephrine

Question 2 (1 pt)